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Mitochondrial Dysfunction and Children with Autism – The Autism Exchange

Introduction

Mitochondria are responsible for generating energy or the power source ATP (adenosine triphosphate) in the cells.  The Mitochondria found in granulocytes, a type of immune cell that fights infection and protects the body from invasion, has one third the capacity it normally should in ASD children.  This means far less oxygen is found in the cells of ASD children.  As a result, oxidative stress and free radicals in the blood cells of ASD children were far greater than those without the disorder.  Symptoms such as low cellular energy, abnormal fatigue, gastrointestinal distress, muscle weakness, hypotonia (low upper body muscle tone), low stamina, seizures, motor delays, neuropsychiatric behaviors, language and social impairment, and endocrine disturbances were identified.  Treating Mitochondrial Dysfunction with nutritional supplementation under the supervision of a physician has found to improve symptoms of autism.

Related Sites

Mitochondrial Disorder Overview
Description:  This site provides parents with overall information of Mitochondrial Disorders including additional symptoms and further resources for parents.

About Autism and Mito (Mitochondrial Dysfunction)
Description:  This site provides information and support for families who are seeking information about ASD and the Mitochondrial Dysfunction.

Books

Cutting-Edge Therapies for Autism Fourth Edition
Description:  Cutting Edge Therapies for Autism provides parents with a go-to handbook which has over 90 autism experts’ contributions with their evaluations, therapies, extensive research information and treatment centers. The Fourth Edition also has the latest up-to-date information regarding Mitochondrial Disorders and autism.

Living Well With Mitochondrial Disease: A Handbook for Patients, Parents, and Families by Cristy Balcells R.N. M.S.N.
Description:  Living Well with Mitochondrial Disease is the perfect handbook for parents and families. Many children with autism are suffering not only from gastrointestinal difficulties but also from debilitating fatigue. Mitochondrial defects cause problems with energy levels and muscle tone. This book will address many of the questions that families have about their child.

Tools

Can Autism Be a Mitochondria Disorder?
Description:  In this video, Richard Frye, MD, PhD, discusses the role of seizures in Mitochondrial Dysfunction and how seizures in ASD are very similar to Mitochondria Dysfunction -- they have similar presentations.

Interview with Dr. Richard Frye
Description:  Dr. Frye discusses his approach related to endophenotypes which means to define the underlying conditions related to specific subsets of children with ASD. He specializes in such conditions as Mitochondria Disorders, seizures, and Cerebral Folate Deficiencies.

Parent Forums/Blogs

Some forums require you to sign in to Yahoo or Facebook to locate forum names.

Forum/Blog Name:  Mitochondrial Autism
Description:  A growing body of research is showing that a number of children diagnosed with Autism may have an underlying mitochondrial or metabolic disorder causing it. This group is to support those on this journey and raise awareness about the connection between mitochondrial disease and autism.

Forum/Blog Name:  Mito Action
Description:  Parent forum for Mitochondrial Dysfunction.

Consumer Corner

The AEX Directory
Description:  We do not provide medical advice on this site. Please consult your practitioner to discuss treatments for medical conditions. We do have a Directory feature that includes Practitioner Lists as well as Supplement Suppliers, Lab Test Companies, Compounding Pharmacies, and Prescription Drug Lookup. This feature can be accessed by clicking the link above or clicking The AEX Directory icon from our home page or any of the Navigation bar pages.

Community Library

Mitochondria Dysfunction in Autism Spectrum Disorders
Description:  Dr. Suzanne Goh, pediatric neurologist, discusses the link between mitochondrial dysfunction in Autism Spectrum Disorder.

Centers for Disease Control and Prevention: Mitochondrial Disease - Frequently Asked Questions
Description:  Some common questions concerning the relationship between mitochondrial disease and autism are answered.




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