Epigenetics and Children with Autism – The Autism Exchange

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<!—Biomedical / Contributing Factors / Epigenetics —> Epigenetics and Children with Autism – The Autism Exchange

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Introduction

For many of us ‘epigenetics’ is not a familiar word, and least of all, that it has something to do with autism.  But the fact of the matter is that it has everything to do with autism.  In 1940, the British embryologist and geneticist Conrad Waddington was the first to coin the term epigenetics and he described it as «the interactions of genes with their environment, which bring the phenotype into being.»  Today, however, researchers are taking epigenetics one step further and looking at how the DNA methylation is being altered.

Basically, toxic environmental exposures can cause abnormal gene expression which is what we are now seeing with the widespread genetic mutation called the Methylenetetrahydrofolate Reductase (MTHFR).  According to the study on the «Association of MTHFR Gene Variants with Autism«, 98% of children with autism carry at least one copy of the MTHFR.  This means there is a defect in the methylation process which ultimately affects the body’s ability to excrete toxins effectively.  See the Methylation/MTHFR section of The Autism Exchange.  The bottom line is environmental factors can trigger changes in our DNA by turning our genes on and off.

Tom Insel MD, Director of the National Institute of Mental Health (NIMH) in his blog «The New Genetics of Autism –Why Environment Matters» states that: «Increasing [autism] prevalence suggests environmental factors like chemicals and microbes changing over the past decade, whereas genes change over generations.  Why is anyone looking for genetic causes when there is such a rapid increase in [autism] prevalence?  Shouldn’t every research dollar be invested in finding the environmental culprit rather than searching for rare gene variants?»

Historically, we have seen that any organism – plant, animal, or human – has somehow found the ability to adapt to various environmental factors in order to survive.  So it should be of no surprise that today adaptation and survival is what humans and their DNA are doing now.  Time Magazine even published an article called «Why Your DNA Is Not Your Destiny» by John Cloud.  Epigenetics not only affects autism, but also affects so many other medical conditions that are on the rise.  We all have to learn how to adapt in order to survive in this toxic world in which we live.

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Related Sites

Epigenetic Findings in Autism: New Perspectives for Therapy
Description:  An article from the International Journal of Environmental Research and Public Health.

The New Genetics of Autism –Why Environment Matters
Description:  A blog by Tom Insel, M.D., Director of the National Institute of Mental Health (NIMH).

Books

Cancer, Autism and Their Epigenetic Roots (McFarland Health Topics) by John Morrow
Description:  Cancer, Autism and Their Epigenetic Roots is an eye opening account of what epigenetics is and how it is impacting our health by creating many more diseases. The book highlights the role of the environment today in creating epigenetics and how this is changing our gene expression.

Epigenetics in Human Disease by Trygve Tollefsbol
Description:  This book gives an excellent explanation of the role of epigenetics in human diseases, cancer, and autoimmune disorders including autism. Evaluations, latest science and breakthrough treatment protocols are all outlined and discussed in these chapters.

Tools

Epigenetics in Autism-Spectrum Disorders with Dr. Janine LaSalle
Description:  Dr. Janine LaSalle covers the epigenetics involved in autism-spectrum disorders.

The PALEO Epigenetic DIET BIBLE: (Lose Weight Permanently) Learn the Science of Slim, Use your Smart Genetics by Beran Parry
Description:  The PALEO Epigenetic Diet Bible is a revolutionary dietary guide that is based on the environmental factors changing your genes which are also affecting the food you eat. Find out how the Paleo diet is most complementary to your changing genetics. Enjoy the delicious recipes which are very much life changing.

Parent Forums/Blogs

Some forums require you to sign in to Yahoo or Facebook to locate forum names.

Forum/Blog Name:  Questioning Answers: Epigenetics 101 and Autism
Description:  Basic information on Epigenetics, Autism, DNA Methylation.

Consumer Corner

The AEX Directory
Description:  We do not provide medical advice on this site. Please consult your practitioner to discuss treatments for medical conditions. We do have a Directory feature that includes Practitioner Lists as well as Supplement Suppliers, Lab Test Companies, Compounding Pharmacies, and Prescription Drug Lookup. This feature can be accessed by clicking the link above or clicking The AEX Directory icon from our home page or any of the Navigation bar pages.

Community Library

The Most Promising Areas of Autism Research
Description:  Article on genetic research in autism.

Epigenetic Theory of Autism: Autism Tornado in the Brain
Description:   “It’s becoming quite clear to more and more of us that autism is not genetic, but epigenetic.” So says William J. Walsh, who received a Ph.D. in chemical engineering from Iowa State University and is an expert in nutritional medicine. In the 1970s, he collaborated with the renowned Dr. Carl Pfeiffer, a pioneer in schizophrenia research, and went on to develop nutrient protocols to normalize brain chemistry in patients with behavioral and personality disorders, schizophrenia, and autism.




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