Pyroluria Disorder and Children with Autism


Pyroluria Disorder and Children with Autism

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Neurobehavioral disorders are often associated with elevated levels of Kryptopyrroluria.  It is a genetic blood disorder and a chemical imbalance that blocks receptor sites to such nutrients as Zinc, and B6 (P5P) as well as Biotin, Omega 6 GLA (Gamma-Linolenic Acid) and others.   The onset normally occurs during the late teens and may continue throughout one’s life.   Favorable conditions triggering this disorder are environmental toxicity, chronic infection (Lyme), genetic predispositions (alcoholism, Bipolar), trauma or traumatic incidences, prolonged stress, oxidative stress or chronic illness.  At least 50% of teens with autism develop Pyroluria. An overproduction of pyrroles (Pyroluria) can results in a zinc deficiency.  Zinc is crucial to regulating the immune, the gastrointestinal and hormonal systems; but a deficiency can lead to chronic immunodeficiency and frequent infections.  Some common symptoms of Pyroluria are high anxiety, frequent mood swings, poor coping skills, poor anger control, frequent anger and rages, insomnia, increased sensitivity to sound, lights, smell, and touch, seizures, poor short term memory, poor tolerance of physical and emotional stress, food and environmental allergies, and hyperactivity to name a few.  Following the work of William Walsh PhD (Pfeiffer Center), a nutrient correction protocol can attenuate symptoms and control the disorder.

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Related Sites

Grow Youthful at Any Age – Pyroluria
Description:  This site contains diagnoses, causes, conditions, symptoms as well as consequences of Pyroluria. In addition, remedies and treatments are offered.

The Klinghardt Academy (Pyroluria)
Description:  Dietrich Klinghardt, MD, PhD, provides a complete comprehensive overview of Kreptopyroluria and HemoPyrrolLactamUria (HPU).

Pyroluria Testimonials
Description:  It is believed to be a factor in larger percentages of people with anxiety, depression, ADHD, alcoholism, autism, and schizophrenia are pyroluric. This site gives testimony to the importance of treating it.

Dr. Jeremy E. Kaslow, MD, FACP, FACAAI,, Pyroluria
Description:  Dr. Kaslow is a Board Certified Allergy, Asthma and Clinical Immunology and Internal Medicine physician with a focus on functional and integrative health. This website provides information specific to Pyroluria, as well as to a variety of other conditions that patients with autism face.


Nutrient Power: Heal Your Biochemistry and Heal Your Brain by William J. Walsh
Description:  This book is science-based and describes individualized nutrient therapy treatments that have helped thousands of people recover from their illnesses. Pages 14, 15, and 27 of this book touch on Pyroluria.

Depression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life by Joan Mathews Larson
Description:  In this book, the author offers an incredible recovery formula for biochemical imbalances affecting your life. Her dietary and nutritional suggestions are key to having a full recovery in a very short period of time. Included are several references to Pyroluria.

The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings by Trudy Scott
Description:  This book is a helpful and informative guide about what foods affect your brain and your emotions. The author’s goal is to assist people with making appropriate nutritional choices to keep stress levels low and have a healthy body, emotions and mind. Chapter 7 addresses the problems for those suffering from Kreptopyryoluria.

Primal Body, Primal Mind: Beyond the Paleo Diet for Total Health and a Longer Life by Nora T.Gedgaudas
Description:  Primal Body, Primal Mind is an excellent guide with recipes and recommendations for healthy meals which don’t include stressful ingredients such as gluten, casein, soy, and grains- the Paleo diet. The author stresses the need for good quality fats and cholesterol for the brain and the importance of vitamin D3. Appendix E is on Pyroluria.


Pyroluria and Adrenal Fatigue Syndrome
Description:  Michael Lam MD talks about pyroluria and adrenal fatigue and what to do about it.

THRiiiVE — Pyroluria Discussed by Dana Gorman
Description:  Dana Gorman describes Pyroluria in this video.

Pyroluria-Anxiety and Depression-Zinc and B6
Description:  This video describes Pyroluria, its associations with autism, and a wide variety of other neurologic disorders.

Pyroluria and Autism
Description:  Dana Gorman from THRiiiVE talks about what Pyroluria is and what symptoms are manifested. She refers to references in Dr. Mercola’s article. (See Library Articles) She also mentions Dr. Dietrich Klinghardt’s suggestion to first address issues of Pyroluria first before beginning any detoxification program.

Parent Forums/Blogs

Some forums require you to sign in to Yahoo or Facebook to locate forum names.

Forum/Blog Name:  Pyroluria
Description:  Pyroluria is a chemical imbalance. Virtually not known to conventional medicine it can cause very serious symptoms. You can find more useful information in the FILES section of this group.

Forum/Blog Name:  Zinc/Copper Balance in Autism/Pyroluria: Dr. Usman
Description:  Dr. Norman Schwartz interviews Dr. Anju Usman about Autism and Pyroluria and the zinc/copper ratios in children with ASD.

Forum/Blog Name:  Pyroluria Support
Description:  This Facebook group provides support and information regarding Pyroluria.

Forum/Blog Name:  Baby Center Community
Description:  Pyroluria — 50% of autistic children.